Friday, February 1, 2013

'Voice of New York' Mayor Ed Koch dead at 88

Ed Koch, the brash, colorful and often confrontational mayor who helped to lead New York City out of its brush with bankruptcy in the 1970s, launching an astonishing municipal turnaround that continues to this day, has died. He was 88.

Koch was recently readmitted to the hospital after being treated for water in his lungs, The Associated Press reported. A spokesman confirmed the news of Koch's death early this morning.

In December, Koch recently battled pneumonia and was being treated with antibiotics and in September, he was hospitalized and was treated for anemia.

Koch took office on Jan 1, 1978 with New York City all but broke. Thousands of cops, firemen, sanitation workers and teachers had been laid off. Bridges were crumbling, the subways were caked in grime and graffiti, and crime was taking off.

Koch helped to restore the city's credit with budget cuts, and he revived the city's spirits with his unflagging enthusiasm for all things New York ? and an unflinching willingness to stand up to opponents.

By the time he left office at the end of 1989, New York was far from problem- free, but Gotham's future no longer was in doubt. "He went at it with a sense of joy, a sense of combat, a sense that made us all know, "That's the voice of New York, that's what we are," the writer Pete Hamill once said.

That voice never held back. Koch was forever dispensing opinions -- and forever asking New Yorkers, "How 'm I doing?" He attacked opponents as "crazy," "wackos" or "radicals." To critics who said he had drifted too far from his liberal roots, Koch said he was "a liberal with sanity."

"Part of the thing that was most refreshing and most appalling about Koch is that he will stand for what he believes in," the Rev. Al Sharpton, who repeatedly jousted with Koch in the 1980s, said in 2005. "He will not say what you want him to. And he will not be intimidated either way."

Koch put it this way: "I'm the sort of person who will never get ulcers. Why? Because I say exactly what I think. I am the sort of person who might give other people ulcers."

When the New York Giants won the Super Bowl in January 1987, Koch refused to allow a ticker-tape parade for the champs because the Giants had left New York for New Jersey's Meadowlands more than a decade earlier.

"If they want a parade, let them parade in front of the oil drums in Moonachie," Koch said, referring to a community near the Meadowlands.

While such outspokenness endeared Koch to constituents, his sharp tongue contributed to his biggest political defeats.

In 1982, while running for governor, Koch gave an interview to Playboy magazine in which he called living in rural areas "a joke" and described suburban living as "wasting your life." To top it off, he called living in the state capital, Albany, "a fate worse than death."

The comments alienated suburban and upstate voters, and Koch lost the Democratic primary to a New York City lawyer named Mario Cuomo, who went on to serve three terms as governor. Koch later called his remarks "the dumbest" he ever made.

Six years later, during the fiercely contested New York Democratic primary for president, Koch said Jewish voters would be "crazy" to support the Rev. Jesse Jackson. The remark infuriated and energized African-American voters, propelling Jackson to a surprising second-place finish behind Michael Dukakis.

The following year, the city's black voters got their revenge, helping Manhattan Borough President David Dinkins beat Koch in the 1989 Democratic primary. Dinkins went on to defeat former U.S. Attorney Rudolph Giuliani to become the city's first black mayor.

Arguably, Koch became even more popular after leaving City Hall. He hosted a radio show, wrote books, reviewed movies and even dispensed justice for a while on television's "The People's Court," succeeding Judge Marvin Wapner.

For years he teamed up with his close friend, former U.S. Sen. Alfonse D'Amato (R-NY), offering opinions and political analysis on the New York cable news station, NY1.

Koch also remained a political force. His endorsements were crucial in helping to elect two Republicans -- Giuliani as mayor of New York, in 1993, and George Pataki, as governor of New York, in 1994. And his backing of then-First Lady Hillary Rodham Clinton, a Democrat, eased the concerns of some older Jewish voters, helping her win a U.S. Senate seat in New York in 2000.

Edward I. Koch was born in the Bronx on Dec. 12, 1924 and reared in Newark, N.J. He served in the Army in World War II, landing in Cherbourg, France in September 1944 and earning two Battle Stars as a combat infantryman.

A graduate of the City College of New York and the New York University School of Law, Koch was a practicing attorney when he entered politics.

"I had no goals at that time, other than to meet people. Make friends," Koch told New York's Paper magazine. "I'm an achiever. I'm a good organizer, and I became a street spokesman for the Village Independent Democrats club. I was out every night on a soapbox."

Inspired by the speeches of presidential candidate Adlai Stevenson, Koch aligned himself with insurgents who opposed Tammany Hall, the long-running but decaying New York Democratic machine. Koch defeated the last Tammany boss, Carmine DeSapio, in a race for Democratic district leader in Greenwich Village in 1963.

The victory propelled Koch to the City Council, and then to Congress, where he served for nine years before winning a four-way Democratic primary for mayor in 1977 by shrewdly tacking to the political center ? a shift that mirrored the political migration of white ethnic Democrats in the 1970s and '80s.

Koch cemented his popularity in 1980 when he acted as a kind of municipal cheerleader when a transit workers strike halted the subways and buses. Day after day, Koch stood on the Brooklyn Bridge, applauding New Yorkers walking to work.

"As I got on the bridge I began to yell, 'Walk over the bridge, walk over the bridge, we're not going to let these bastards bring us to our knees!' And people began to applaud. I knew I was onto something," he recalled in 2011.

During his administration, the go-go years on Wall Street in the 1980s led the city to new economic prosperity. He created a housing program which, over a ten year period, provided more than 150,000 units of affordable housing financed by city funds.

But Koch's brand of governing was not without dissenters. Koch had a troubled relationship with black voters. The relationship began its downward slide in 1978 with the death of a black businessman while he was in police custody. Other alleged cases of police brutality followed.

Racial unrest, his comments about Jesse Jackson, a municipal corruption scandal and soaring crime and homelessness doomed Koch's bid for an unprecedented fourth term.

Although Koch's endorsement helped Giuliani win 1993 mayoral race, the two had a falling out over what Koch saw as Giuliani's combative and authoritarian ways. Koch went on to write a book about it, Giuliani: Nasty Man.

Koch also wrote Citizen Koch; Ed Koch on Everything; I'm Not Done Yet: Remaining Relevant; and Eddie, Harold's Little Brother, a children's book which he co-authored with his sister, Pat Koch Thaler. He also teamed up with his good friend, John Cardinal O'Connor, who led the Archdiocese of New York, in writing, His Eminence and Hizzoner, which traced Koch's shift to more centrist and conservative positions.

Koch will spend eternity in his beloved Manhattan. He announced in 2008 that he had purchased a plot at the Trinity Church cemetery, after learning that the church permits Jews to be buried there. It is the only active cemetery left in Manhattan.

"I don't want to leave Manhattan, even when I'm gone. This is my home," Koch explained. "The thought of having to go to New Jersey was so distressing to me."

The Associated Press contributed to this report.

Source: http://news.yahoo.com/ed-koch--the-mayor-who-kept-nyc-from-going-broke--dies-at-88-130516500.html

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US looking at action against China cyberattacks

WASHINGTON (AP) ???The Obama administration is considering more assertive action against Beijing to combat a persistent cyber-espionage campaign it believes Chinese hackers are waging against U.S. companies and government agencies.

As The New York Times and Wall Street Journal reported Thursday that their computer systems had been infiltrated by China-based hackers, cybersecurity experts said the U.S. government is eyeing more pointed diplomatic and trade measures.

Two former U.S. officials said the administration is preparing a new National Intelligence Estimate that, when complete, is expected to detail the cyberthreat, particularly from China, as a growing economic problem. One official said it also will cite more directly a role by the Chinese government in such espionage.

Related story:?Officials say Chinese spies have targeted every sector of the U.S. economy

The official said the NIE, an assessment prepared by the National Intelligence Council, will underscore the administration's concerns about the threat, and will put greater weight on plans for more aggressive action against the Chinese government. The official was not authorized to discuss the classified report and spoke only on condition of anonymity.

Although the administration hasn't yet decided what steps it may take, actions could include threats to cancel certain visas or put major purchases of Chinese goods through national security reviews.

"The U.S. government has started to look seriously at more assertive measures and begun to engage the Chinese on senior levels," said James Lewis, a cybersecurity expert at the Center for Strategic and International Studies. "They realize that this is a major problem in the bilateral relationship that threatens to destabilize U.S. relations with China."

Chinese deny attacks
To date, extensive discussions between Chinese officials and top U.S. leaders ? including President Barack Obama and Defense Secretary Leon Panetta ? have had little impact on what government and cybersecurity experts say is escalating and technologically evolving espionage. The Chinese deny such espionage efforts.

Internet search leader Google focused attention on the China threat three years ago by alleging that it had traced a series of hacking attacks to that country. The company said the breaches, which became known as "Operation Aurora," appeared aimed at heisting some of its business secrets, as well as spying on Chinese human rights activists who relied on Google's Gmail service. As many as 20 other U.S. companies were also said to be targeted.

A four-month long cyberattack against The New York Times is the latest in a long string of breaches said to be by China-based hackers into corporate and government computer systems across the United States. The Times attacks, routed through computers at U.S. universities, targeted staff members' email accounts, the Times said, and were likely in retribution for the newspaper's investigation into the wealth amassed by the family of a top Chinese leader.

The Wall Street Journal on Thursday said that its computer systems, too, had been breached by China-based hackers in an effort to monitor the newspaper's coverage of China issues.

Media organizations with bureaus in China have believed for years that their computers, phones and conversations were likely monitored on a fairly regular basis by the Chinese. The Gmail account of an Associated Press staffer was broken into in China in 2010.

A more 'personal element'
Richard Bejtlich, the chief security officer at Mandiant, the firm hired by the Times to investigate the cyberattack, said the breach is consistent with what he routinely sees China-based hacking groups do. But, he said it had a personal aspect to it that became apparent: The hackers got into 53 computers but largely looked at the emails of the reporters working on a particular story. The newspaper's investigation delved into how the relatives and family of Premier Wen Jiabao built a fortune worth over $2 billion.

"We're starting to see more cases where there is a personal element," Bejtlich said, adding that it gives companies another factor to consider. "It may not just be the institution, but, is there some aspect of your company that would cause someone on the other side to take personal interest in you?"

Journalists are popular targets, particularly in efforts to determine what information reporters have and who may be talking to them.

The Chinese foreign and defense ministries called the Times' allegations baseless, and the Defense Ministry denied any involvement by the military.

"Chinese law forbids hacking and any other actions that damage Internet security," the Defense Ministry said. "The Chinese military has never supported any hacking activities. Cyberattacks are characterized by being cross-national and anonymous. To accuse the Chinese military of launching cyberattacks without firm evidence is not professional and also groundless."

In a report in November 2011, U.S. intelligence officials for the first time publicly accused China and Russia of systematically stealing American high-tech data for economic gain. And over the past several years, cybersecurity has been one of the key issues raised with allies as part of a broader U.S. effort to strengthen America's defenses and encourage an international policy on accepted practices in cyberspace.

Concern about Iran, Russia cyberthreats
U.S. cybersecurity worries are not about China alone. Administration officials and cybersecurity experts also routinely point to widespread cyberthreats from Iran and Russia, as well as hacker networks across Eastern Europe and South America

The U.S. itself has been named in one of the most prominent cyberattacks ? Stuxnet ? the computer worm that infiltrated an Iranian nuclear facility, shutting down thousands of centrifuges there in 2010. Reports suggest that Stuxnet was a secret U.S.-Israeli program aimed at destabilizing Iran's atomic energy program, which many Western countries believe is a cover for the development of nuclear weapons.

The White House declined comment on whether it will pursue aggressive action on China.

"The United States has substantial and growing concerns about the threats to U.S. economic and national security posed by cyber intrusions, including the theft of commercial information," said spokesman Caitlin Hayden. "We have repeatedly raised our concerns with senior Chinese officials, including in the military, and we will continue to do so."

Cybersecurity experts have been urging tougher action, suggesting that talking with China has had no effect.

"We need to find new approaches if we want to dissuade this type of activity," said Stewart Baker, former assistant secretary at the Department of Homeland Security and now in private law practice with Steptoe and Johnson in Washington. He said the U.S. must do a better job of attributing the cyberattacks to particular groups or nations and "see if we can sanction the people who are actually benefiting from them."

Slowly stepping up rhetoric
The Obama administration has slowly been ratcheting up its rhetoric. In an unusually strong speech last October, Panetta warned that the U.S. would strike back against cyberattacks, even raising the specter of military action. And the White House has been urging Congress to authorize greater government action to protect infrastructure such as the nation's electric grid and power plants.

Alan Paller, director of research at SANS Institute, a computer-security organization, said that the level of cyberattacks, including against power companies and critical infrastructure, has shot up in the last seven or eight months. And the U.S. is getting more serious about blocking the attacks, including an initiative by the Defense Department to hire thousands of high-tech experts.

Just talking about it, he said, is having no effect.

Lewis, who has met and worked with Chinese officials on the issue, said their response has been consistent denial that China is involved in the hacking and counter-accusations that the U.S. is guilty of the same things.

"In the next year there will be an effort to figure out a way to engage the Chinese more energetically," he said. "The issue now is how do we get the Chinese to take this more seriously as a potentially major disruption to the relationship."

The answer, he said, is, "You have to back up words with actions, and that's the phase I think we're approaching."

Associated Press writer Michael Lietdke contributed to this report from San Francisco.?

Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.nbcnews.com/technology/technolog/us-looking-action-against-china-cyberattacks-1B8202819

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Correlations between cytoplasmic CSE1L in neoplastic colorectal ...

Open Access Research

Cheng-Jeng Tai, Tzu-Cheng Su, Ming-Chung Jiang, Hung-Chang Chen, Shing-Chuan Shen, Woan-Ruoh Lee, Ching-Fong Liao, Ying-Chun Chen, Shu-Hui Lin, Li-Tzu Li, Ko-Hung Shen, Chung-Min Yeh, Kun-Tu Yeh, Ching-Hsiao Lee, Hsin-Yi Shih and Chun-Chao Chang

For all author emails, please log on.

Journal of Translational Medicine 2013, 11:29?doi:10.1186/1479-5876-11-29

Published: 31 January 2013

Abstract (provisional)

Background

Colorectal carcinomas spread easily to nearby tissues around the colon or rectum, and display strong potential for invasion and metastasis. CSE1L, the chromosome segregation 1-like protein, is implicated in cancer progression and is located in both the cytoplasm and nuclei of tumor cells. We investigated the prognostic significance of cytoplasmic vs. nuclear CSE1L expression in colorectal cancer.

Methods

The invasion- and metastasis-stimulating activities of CSE1L were studied by in vitro invasion and animal experiments. CSE1L expression in colorectal cancer was assayed by immunohistochemistry, with tissue microarray consisting of 128 surgically resected specimens; and scored using a semiquantitative method. The correlations between CSE1L expression and clinicopathological parameters were analyzed.

Results

CSE1L overexpression was associated with increased invasiveness and metastasis of cancer cells. Non-neoplastic colorectal glands showed minimal CSE1L staining, whereas most colorectal carcinomas (99.2%, 127/128) were significantly positive for CSE1L staining. Cytoplasmic CSE1L was associated with cancer stage (P=0.003) and depth of tumor penetration (P=0.007). Cytoplasmic CSE1L expression also correlated with lymph node metastasis of the disease in Cox regression analysis

Conclusions

CSE1L regulates the invasiveness and metastasis of cancer cells, and immunohistochemical analysis of cytoplasmic CSE1L in colorectal tumors may provide a useful aid to prognosis.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

Source: http://www.translational-medicine.com/content/11/1/29

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Google most important source of referral traffic for B2B sites

Google continues to be the single biggest source of referral traffic for B2B websites, despite the growth that has been seen in social media.

The 2012 B2B Marketing Benchmark report from Optify revealed Google is responsible for 36 per cent of traffic to B2B websites.?

In total, organic search contributes 41 per cent of traffic to B2B websites, significantly more than paid search, which accounts for just four per cent of traffic.

Google was found to be responsible for 90 per cent of organic search traffic, however the research revealed traffic from Bing recorded more page views per visit and better conversion rates than Google.

Organic search was also revealed as the second biggest source for leads at 26 per cent, behind direct traffic with 34 per cent.

With organic search forming such a major part of traffic to B2B websites, it's essential companies have a comprehensive SEO strategy in place which recognises the importance of high quality content in achieving a high search ranking.

B2B trends in social media

Optify's research also assessed the impact of social media on B2B websites. On average social media sites were found to contribute less than five per cent of traffic and leads.

Twitter is the strongest social network for generating leads, accounting for 82 per cent of social media leads and outperforming professional social network LinkedIn.

Email marketing was found to generate lower levels of traffic (0.8 per cent), but a higher proportion of leads. Email was found to deliver both high engagement rates and high conversion rates.

However, the importance of social media for brand building and word-of-mouth recommendations should not be overlooked.

Research from Nielsen found 77 per cent of people believe recommendations from friends and family when looking to try a new product or service, higher than the number who say searching for a product online or television advertising influenced their decision.?

Source: http://www.newsreach.co.uk/seo/google-most-important-source-of-referral-traffic-for-b2b-sites

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Thursday, January 31, 2013

Powerful storm flips cars, decimates homes; 2 dead

A vehicle lies on a road after a tornado moved through Adairsville, Ga. on Wednesday, Jan. 30, 2013. A fierce storm system that roared across northwest Georgia has left at least one person dead and a trail of damage that included demolished buildings in downtown Adairsville and vehicles overturned on Interstate 75 northwest of Atlanta. (AP Photo/David Goldman)

A vehicle lies on a road after a tornado moved through Adairsville, Ga. on Wednesday, Jan. 30, 2013. A fierce storm system that roared across northwest Georgia has left at least one person dead and a trail of damage that included demolished buildings in downtown Adairsville and vehicles overturned on Interstate 75 northwest of Atlanta. (AP Photo/David Goldman)

In this image made from video and released by WSB TV in Atlanta, a tornado moves through the town of Adairsville, Ga. on Wednesday, Jan 30, 2013. A fire chief says a storm that roared across northwest Georgia has left overturned vehicles on Interstate 75 northwest of Atlanta, and crews are responding to reports of people trapped in storm-damaged residential and commercial buildings. (AP Photo/WSB TV) MANDATORY CREDIT

In this image made from video and released by WSB TV in Atlanta, a tornado moves through the town of Adairsville, Ga. on Wednesday, Jan 30, 2013. A fire chief says a storm that roared across northwest Georgia has left overturned vehicles on Interstate 75 northwest of Atlanta, and crews are responding to reports of people trapped in storm-damaged residential and commercial buildings. (AP Photo/WSB TV) MANDATORY CREDIT

Jean Fogus, left, and her daughter Pamela Luna stand on there porch after tornado touched down damaging the siding, uprooted a tree and knocked out power to there home along Batson Drive Wednesday, Jan. 30, 2013, in Ashland City, Tenn. (AP Photo/Mark Zaleski)

Thomas Ivey carries section of a tree he cut up after it was blown over by tornado that hit the corner of his friend's house Wednesday, Jan. 30, 2013, in Ashland City, Tenn. Around 25 homes in Ashland City had minor damage. (AP Photo/Mark Zaleski)

(AP) ? A massive storm system raked the Southeast on Wednesday, spawning tornadoes and dangerous winds that overturned cars on a major Georgia interstate and demolished homes and businesses, killing at least two people.

In northwest Georgia, the storm system tossed vehicles on Interstate 75 onto their roofs. The highway was closed for a time, and another main thoroughfare remained closed until crews could safely remove downed trees and power lines from the road.

WSB-TV in Atlanta aired footage showing an enormous funnel cloud bearing down on Adairsville, about 60 miles northwest of Atlanta, as the storm ripped through the city's downtown area. The system flattened homes and wiped out parts of a large manufacturing plant. Pieces of insulation hung from trees and power poles, while the local bank was missing a big chunk of its roof.

One person was killed and nine were hospitalized for minor injuries, state emergency management officials said. Residents said no traces remained of some roadside produce stands ? a common sight on rural Georgia's back roads.

One other death was reported in Tennessee after an uprooted tree fell onto a storage shed where a man had taken shelter.

In Adairsville, the debris in one yard showed just how dangerous the storm had been: a bathtub, table, rolls of toilet paper and lumber lay in the grass next to what appeared to be a roof. Sheets of metal dangled from a large tree like ornaments.

"The sky was swirling," said Theresa Chitwood, who owns the Adairsville Travel Plaza. She said she went outside to move her car because she thought it was going to hail. Instead, the passing storm decimated a building behind the travel plaza.

Powerful winds ripped through the entire region, with gusts powerful enough to topple tractor-trailers in several places.

In Adairsville, several were flipped on their side in the parking lot of the travel plaza. Danny Odum and Rocky Depauw, both truckers from Marion, Ill., had stopped for breakfast when the suspected tornado hit.

The pair had been driving their trucks through storm warnings all night long. When they got to the restaurant in Adairsville they went inside to eat. Depauw got a weather alert on his phone, and about two minutes later they saw debris flying through the parking lot and ran for an inner room.

"I've been stopping here for probably 40 years," Odum said. "I just stopped and had breakfast this morning, and this happened."

After it passed, Odum said he went outside to find his truck that was hauling diapers on its side with his dog Simon, a Boston terrier, still inside. Simon was scared but otherwise fine.

Depauw's truck was parked next to Odum's and was damaged but still upright. He speculated his heavy haul of cat litter may have helped his truck handle the hit better than his friend's.

Not far down the road, at Owen's Bar-B-Que, Chrystal Bagley and her coworkers heard warnings about severe weather on the radio, but they didn't hear Adairsville included in the list of warning areas. Around 11:45 a.m., the doors started rattling, and chairs and knick-knacks began blowing around the room as the door flapped open.

"We heard this big old whooshing noise like a train, and then we ran to the restroom, but we had to dodge objects," she said. "It was real scary."

By the time they reached the restroom, the 20 seconds of a roaring noise and shaking walls had stopped, and everyone was OK.

Bartow County fire chief Craig Millsap said there were reports that two storm warning sirens may have failed, but he said the failed sirens were not in the hardest-hit area.

Access to the area was being restricted, and there was a report of a gas leak in the area, officials said. A shelter was being established at a community recreation center ? temperatures were expected to plummet to the 30s and 40s overnight.

Authorities were still investigating several sites to determine if damage was caused by twisters. Since Tuesday, the system had caused damage across a swath from Missouri to Georgia.

In recent days, people in the South and Midwest had enjoyed unseasonably balmy temperatures in the 60s and 70s. A system pulling warm weather from the Gulf of Mexico was colliding with a cold front moving in from the west, creating volatility.

One person was reported injured by lightning in Arkansas during the storm's eastward trek. Two people suffered minor injuries when a mobile home was blown off its foundation in Kentucky. Only one minor injury was reported in Mississippi, where officials praised residents for heeding warnings and being prepared.

In Tennessee, officials confirmed that a tornado with peak wind speeds of 115 mph touched down in Mount Juliet. No serious injuries were reported there, though the path of damage was about 150 yards wide, including homes, a warehouse and an automotive business. At least six other tornadoes were reported statewide.

At a shopping center in Mount Juliet, large sheets of metal littered the parking lot, light poles were knocked down and bits of fiberglass insulation were stuck in the trees.

One wall of a Dollar General convenience store collapsed, and the roof was torn off. Mark Fulks Jr. runs Mark's Automotive with his father in a building attached to the Dollar General. The garage door was blown off his shop and sitting on one of the cars inside, and Fulks said several of the cars they were working on had their windshields blown out.

A nearby office building and a distribution center for The Tennessean newspaper also had severe damage. Rick Martin, who bags the newspapers and helps his wife deliver them, was shocked when he saw what was left of the distribution center.

The metal frame of the building still stood, but its cinderblock walls had crumbled, and papers and plastic bags littered the trees.

"We feel real lucky," he said Wednesday morning as looked at the damage. "I would have hated to be in here when this happened."

The deaths reported Wednesday ended the nation's longest break between tornado fatalities since detailed tornado records began being kept in 1950, according to the Storm Prediction Center and National Climatic Data Center. The last one was June 24, when a person was killed in a home in Highlands County, Fla. That was 220 days ago as of Tuesday.

The last day with multiple fatalities was June 4, when three people were killed in a mobile home in Scott County, Mo.

___

Associated Press writers Kristin M. Hall in Mount Juliet, Tenn., and Phillip Lucas in Atlanta contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-01-30-US-Winter-Weather/id-f1799971db1f4e92b47c983942d45404

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LG Spirit 4G arrives on MetroPCS, delivers 4.5-inch display and ICS to the budget-minded crowd

LG Spirit 4G arrives on MetroPCS, delivers 45inch display and ICS to the budgetminded crowd

We are definitely no strangers to seeing MetroPCS bring well-priced, decently-specced Android handsets to market, and we have a feeling that's something potential and current subscribers certainly appreciate. Because, well, who doesn't like choice? With today's LG Spirit 4G launch, MetroPCS continues to expand its LTE-at-a-bargain ideals, announcing a smartphone that carries some pretty decent specs for being contract-free and costing a mere 269 bucks. Naturally, the 4.5-inch display is among the Spirit's main highlights, but there's also an unspecified 1.2GHz, dual-core CPU, a 5-megapixel rear shooter capable of 1080p video, and Ice Cream Sandwich, to boot. The carrier's quick to point out that its newly introduced slab is a follow-up to that LG Motion 4G we saw last year, and that it's compatible with those LTE plans which were unveiled earlier this month. It's worth noting that while the LG Spirit 4G's official MSRP is $269, MetroPCS will have it up for grabs, starting today, at the cheaper price of $199 -- that, of course, after a beloved mail-in rebate and for "a limited time" only. You'll find a couple more press shots after the break, and be sure to hit the source link if you're interested in grabbing one of these for yourself.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/XfiqdVoY1pY/

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Wednesday, January 30, 2013

Ask the Experts: Can Aging Be Controlled?

Judith Campisi, aging Judith Campisi began her career studying cancer, but now investigates the molecular causes of aging Image: Berkeley Lab

Scientists have long thought that aging could be caused by molecular damage that accumulates in our bodies over the course of time. The damage is an unavoidable by-product of breathing oxygen and other metabolic processes that are necessary to life. Eventually, damaged cells stop working, or worse, adopt new functions that trigger cancerous growth or degrade important tissues in the brain, skin and other organs.

But as Melinda Wenner Moyer reports in the February issue of Scientific American, investigators have conducted several experiments over the past few years that challenge this so-called oxidative stress theory of aging. For example, a tiny mouselike creature known as the naked mole rat manages to live up to 30 years (about 10 times longer than a similarly sized mouse) despite accumulating a much greater level of oxidative damage in its tissues than other rodents.

These and other often surprising results have led to a boom in research on aging in the past few years, as investigators learn more about the inner workings of the cells at the molecular and genetic levels.

Scientific American spoke to Judith Campisi, a professor at the Buck Institute for Research on Aging and senior scientist at the Lawrence Berkeley National Laboratory, for a quick overview of the field. You can read more about Campisi?s research on cell senescence as one possible cause of aging in the August 2012 issue of Scientific American.

[An edited transcript of the interview follows.]

Why is it so hard to figure out what causes aging?
In many ways we already know what causes aging. We just don't know what causes aging in the kind of molecular detail that would allow us to intervene in large meaningful ways. It's not even clear that once we solve those mysteries we will be able to intervene in aging or dramatically extend longevity.

I started my career studying cancer. Look at all the things we have learned since the 1970s about how cancers form in the body. And yet, still the best cures we have for most cancers are sledgehammers. Biology is complex?and this is a reality that the public has to come to grips with and our legislators have to come to grips with.

I predict aging will follow the same trajectory as cancer research. Why is aging so difficult to figure out? It's because it's a really tough problem. I think it's tougher than cancer. The time has come to really wallow in the complexities.

How many different causes of aging do you think there will turn out to be?
I don't think there will be hundreds of causes of aging. But I don't think there will be just one, either, or we would have gotten a handle on it by now. It's sort of like asking me what the stock market would be tomorrow. I could give you an answer but you'd be crazy to believe me!

How about just a couple causes of aging?
Well, we know that there is molecular damage and what I will refer to as genetic damage?although that doesn't necessarily mean a mutation. By genetic damage, I am referring to both changes in the genes themselves as well as in the epigenetic switches that regulate how the genes are expressed.

Why does this damage occur? Basically, there are two main reasons: One, breathing oxygen is dangerous to your health. Your body makes certain harmful compounds just as a result of breathing oxygen. Two, the cells inside your body make mistakes when they divide. Most of the cells in your body are not dividing at any given time. Many have the ability to divide but? don't. But when a cell does divide, it has to copy three billion base pairs of DNA exactly right. Inevitably mistakes happen and cells become damaged.

Source: http://rss.sciam.com/click.phdo?i=d3730db928c72914976f0bfbd189b37c

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